KMID : 0603820080140030139
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Journal of Experimental & Biomedical Science 2008 Volume.14 No. 3 p.139 ~ p.146
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Peroxisome Proliferator-activated Receptor ¥ã Is Not Associated with Adipogenesis in Female Mice
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Yoon Mi-Chung
Jeong Sun-Hyo
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Abstract
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The peroxisome proliferator-activated receptor ¥ã (PPAR¥ã) plays a central role in adipogenesis and lipid storage. The PPAR¥ã ligands, thiazolidinediones (TZDs), enhance in vitro adipogenesis in several cell types, but the role of the TZDs on in vivo adipogenesis is still poorly understood. To investigate how PPAR¥ã ligand troglitazone regulates adipogenesis in female mice, we examined the effects of the troglitazone on adipose tissue mass, morphological changes of adipocytes, and the expression of PPAR¥ã target and adipocyte-specific genes in low fat diet-fed female C57BL/6 mice. Administration of troglitazone for 13 weeks did not change body and total white adipose tissue weights compared with control mice. Troglitazone treatment also did not cause a significant decrease in the average size of adipocytes in parametrial adipose tissue although it is reported to increase the number of small adipocytes in male animals. Troglitazone did not affect the mRNA expression of PPAR¥ã and its target genes as well as adipocyte-specific genes in parametrial adipose tissue. These results suggest that PPAR¥ã does not seem to be associated with adipogenesis in females with functioning ovaries and that its inability to induce adipogenesis may be due to sex-related factors.
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KEYWORD
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Troglitazone, PPAR¥ã(peroxisome proliferator-activated receptor ¥ã), Adipogenesis, Female, Sex
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